منابع مشابه
Hydrocortisone therapy for patients with septic shock.
BACKGROUND Hydrocortisone is widely used in patients with septic shock even though a survival benefit has been reported only in patients who remained hypotensive after fluid and vasopressor resuscitation and whose plasma cortisol levels did not rise appropriately after the administration of corticotropin. METHODS In this multicenter, randomized, double-blind, placebo-controlled trial, we assi...
متن کاملSteroid therapy of septic shock.
Steroid therapy in patients with septic shock has been controversial for decades. Although treatment with high-doses of corticosteroids for patients with septic shock has been shown not to be beneficial, it was believed that therapy with low-doses would be helpful. Recent studies document that steroids are beneficial only in adult septic shock patients whose blood pressure is poorly responsive ...
متن کاملIntensive insulin therapy in septic shock.
The use of intensive insulin therapy (IIT) to maintain blood glucose level below 8.3 mmol/L is recommended for management of severe sepsis by the Surviving Sepsis guidelines. The recent trials reporting reduced morbidity and mortality in critically ill patients treated with IIT require careful examination, including the subsequent post-hoc analyses. An understanding of the molecular and metabol...
متن کاملPolymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملAlternative Therapies for Septic Shock: Beyond Early Goal-Directed Therapy
Severe sepsis and septic shock are major concerns within our health care system, accounting for 2.26 cases per 100 hospital discharges (Angus et al., 2001). The incidence of sepsis has increased by 9% each year (Martin et al., 2003), and mortality ranges from 17.9% to 70% depending on severity of disease and factors such as age, sex, ethnic origin, and comorbidities (Angus et al., 2001; Martin ...
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ژورنال
عنوان ژورنال: Nihon Shuchu Chiryo Igakukai zasshi
سال: 2006
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.13.209